| 2022-04-02 18:15:212 April 2022 |   Thonon Black Panthers — LG OLED Las Rozas Black Demons | 12 - 6 | Championship 1/8 | Stade Joseph Moynat, Thonon les Bains |
| 2022-04-23 12:45:5423 April 2022 |   Belgrade SBB Vukovi — Vienna Danube Dragons | 21 - 35 | Championship 1/8 | FC Rakovica, Belgrade |
| 2022-04-23 14:00:5223 April 2022 |   Copenhagen Towers — Örebro Black Knights | 25 - 56 | Championship 1/8 | Gentofte Sportspark, Copenhagen |
| 2022-04-23 18:00:3323 April 2022 |   Badalona Dracs — Flash de La Courneuve | 7 - 49 | Championship 1/8 | Estadio Municipal, Badalona |
| 2022-04-23 18:30:0323 April 2022 |   Budapest Wolves — Moscow Spartans | 35 - 0 | Championship 1/8 | CANCELED |
| 2022-05-07 17:00:487 May 2022 |  Schwäbisch Hall Unicorns — Örebro Black Knights | 58 - 7 | Championship 1/4 | Optima Sportpark, Schwäbisch Hall |
| 2022-05-14 15:00:5714 May 2022 |  E-R Parma Panthers — Vienna Danube Dragons | 21 - 10 | Championship 1/4 | Lanfranchi Stadium, Parma |
| 2022-05-14 18:00:1214 May 2022 | Thonon Black Panthers — Flash de La Courneuve | 27 - 45 | Championship 1/4 | Stade Joseph Moynat, Thonon les Bains |
| 2022-05-14 18:00:3714 May 2022 |  Calanda Broncos — Budapest Wolves | 35 - 28 | Championship 1/4 | Sportplatz Ringstrasse, Chur |
| 2022-06-04 17:00:384 June 2022 | Schwäbisch Hall Unicorns — Flash de La Courneuve | 35 - 21 | Championship 1/2 | Optima Sportpark, Schwäbisch Hall |
| 2022-06-04 18:00:464 June 2022 | Calanda Broncos — E-R Parma Panthers | 9 - 21 | Championship 1/2 | Sportplatz Ringstrasse, Chur |
Vysočina Gladiators — Prague Lions
Kragujevac Wild Boars — Fehervar Enthroners
Prague Lions — Tychy Falcons
